We took our 9 1/2 year old sheltie, Jasmine to the vet for leaking urine last week. They ran the urine and it was fine, except for being a little dilute, it was an afternoon sample after she'd been drinking. Any ways they also did a senior blood panel and everything came back good. So they put her on prion 25mg, 2xs a day. Our 13 year old sheltie, Mandy has been on prion for over 6 years and it works great. Jasmine has been on it since last Thursday night, she has only leaked once, but she's been drinking like a fish, since she's been on it, and been asking to go out a lot. Anybody else have any issues with Proin causing the dog to be really thirsty. I looked it up online and have found quite a few posts where it says it can be a side effect. She doesn't have any issues at night, holds it for over 9 hours.